GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs10767971 | 1 | rs10767972 | chr11:32896419 | CCDC73 | chr11:32623627-32816187:- | 0.21 | 5.83 | 7.35E-9 | Parkinson's disease (age of onset) |
| BRCA | cis | rs10767971 | 1 | rs10767972 | chr11:32896419 | QSER1 | chr11:32914792-33014862:+ | 0.09 | 3.88 | 0.00011 | Parkinson's disease (age of onset) |
| BRCA | cis | rs10770857 | 1 | rs10770856 | chr12:8705406 | CLEC4D | chr12:8666136-8674958:+ | -0.12 | -4.25 | 2.34E-5 | Response to radiotherapy in prostate cancer (overall toxicity) |
| BRCA | cis | rs10770857 | 1 | rs10770857 | chr12:8705469 | CLEC4D | chr12:8666136-8674958:+ | 0.12 | 4.42 | 1.08E-5 | Response to radiotherapy in prostate cancer (overall toxicity) |
| BRCA | cis | rs10771431 | 1 | rs10771431 | chr12:9380859 | LOC642846 | chr12:9436253-9466684:+ | 0.15 | 6.32 | 3.94E-10 | Breast size |
| BRCA | cis | rs7953704 | 1 | rs10773037 | chr12:122607916 | LRRC43 | chr12:122652266-122688017:+ | -0.17 | -4.85 | 1.42E-6 | Urate levels |
| BRCA | cis | rs7665090 | 1 | rs1077358 | chr4:103553926 | MANBA | chr4:103552644-103682151:- | 0.21 | 5.45 | 6.38E-8 | Primary biliary cirrhosis |
| BRCA | cis | rs1165669 | 1 | rs10778305 | chr12:104311974 | HSP90B1 | chr12:104324189-104341703:+ | -0.13 | -3.41 | 0.000677 | Coronary heart disease |
| BRCA | cis | rs1165669 | 1 | rs10778305 | chr12:104311974 | NT5DC3 | chr12:104164231-104234975:- | -0.14 | -3.4 | 0.000704 | Coronary heart disease |
| BRCA | cis | rs10444533 | 1 | rs10778511 | chr12:107225331 | C12orf23 | chr12:107349544-107367811:+ | -0.16 | -4.25 | 2.34E-5 | Social autistic-like traits |
| BRCA | cis | rs10444533 | 1 | rs10778511 | chr12:107225331 | MTERFD3 | chr12:107371069-107380929:- | -0.15 | -4.35 | 1.51E-5 | Social autistic-like traits |
| BRCA | cis | rs7267979 | 1 | rs1077889 | chr20:25267893 | FAM182A | chr20:26035250-26067552:+ | -0.22 | -5.84 | 6.84E-9 | Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs7267979 | 1 | rs1077889 | chr20:25267893 | FAM182B | chr20:25744102-25848786:- | 0.22 | 5.62 | 2.46E-8 | Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs7267979 | 1 | rs1077889 | chr20:25267893 | PYGB | chr20:25228706-25278647:+ | -0.13 | -3.46 | 0.000553 | Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs7515577 | 1 | rs10782922 | chr1:92974595 | EVI5 | chr1:92974255-93257961:- | -0.18 | -4.86 | 1.37E-6 | Cholesterol, total |